Alternative empiric therapy to carbapenems in management of drug resistant gram negative pathogens: a new way to spare carbapenems

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Alternative empiric therapy to carbapenems in management of drug resistant gram negative pathogens: a new way to spare carbapenems

Background: Increasing prevalence of carbapenem resistance in Gram negative bacteria due to excessive and indiscriminate use of carbapenems has forced the medical fraternity to find out ways to spare carbapenems. This retrospective study was aimed to explore a new fixed dose combination (FDC) of ceftriaxone+sulbactam with adjuvant disodium edetate as a carbapenem sparing drug in the management ...

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The KPC type beta-lactamases: new enzymes that confer resistance to carbapenems in Gram-negative bacilli.

Antimicrobial resistance due to the continuous selective pressure from widespread use of antimicrobials in humans, animals and agriculture has been a growing problem for last decades. KPC beta-lactamases hydrolyzed beta-lactams of all classes. Especially, carbapenem antibiotics are hydrolyzed more efficiency than other beta-lactam antibiotics. The KPC enzymes are found most often in Enterobacte...

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Therapy of Infections due to Carbapenem-Resistant Gram-Negative Pathogens

The prevalence of carbapenem-resistant gram-negative bacterial pathogens (CRGNs) has increased dramatically during the last 10 years, but the optimal treatment for CRGN infections is not well established due to the relative scarcity of robust clinical data. The polymyxins remain the most consistently active agents against CRGNs in vitro. Tigecycline, based on its in vitro antibacterial spectrum...

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Mutant prevention concentrations of four carbapenems against gram-negative rods.

We tested the propensities of four carbapenems to select for resistant Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii mutants by determining the mutant prevention concentrations (MPCs) for 100 clinical strains with various ss-lactam phenotypes. Among the members of the Enterobacteriaceae family and A. baumannii strains, the MPC/MIC ratios were mostl...

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The role of carbapenems in initial therapy for serious Gram-negative infections

The treatment of patients with serious Gram-negative infections must be both prompt and correct. Numerous studies have demonstrated that mortality risk is significantly increased when the initial antibiotic regimen does not adequately cover the infecting pathogen. Furthermore, changing to an appropriate regimen once culture results are available does not reduce this risk. Therefore, one must em...

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ژورنال

عنوان ژورنال: Research Journal of Infectious Diseases

سال: 2015

ISSN: 2052-5958

DOI: 10.7243/2052-5958-3-2